2jph

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==About this Structure==
==About this Structure==
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2JPH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPH OCA].
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2JPH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPH OCA].
==Reference==
==Reference==
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Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain., Tong Y, Hota PK, Hamaneh MB, Buck M, Structure. 2008 Feb;16(2):246-58. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18275816 18275816]
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<ref group="xtra">PMID:18275816</ref><ref group="xtra">PMID:15642257</ref><ref group="xtra">PMID:15929008</ref><ref group="xtra">PMID:15297673</ref><ref group="xtra">PMID:11035813</ref><ref group="xtra">PMID:11267870</ref><ref group="xtra">PMID:17916560</ref><references group="xtra"/>
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When monomers are preferred: a strategy for the identification and disruption of weakly oligomerized proteins., Tong Y, Hughes D, Placanica L, Buck M, Structure. 2005 Jan;13(1):7-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15642257 15642257]
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+
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1H, 15N and 13C Resonance assignments and secondary structure determination reveal that the minimal Rac1 GTPase binding domain of plexin-B1 has a ubiquitin fold., Tong Y, Buck M, J Biomol NMR. 2005 Apr;31(4):369-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15929008 15929008]
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The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras., Oinuma I, Ishikawa Y, Katoh H, Negishi M, Science. 2004 Aug 6;305(5685):862-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15297673 15297673]
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The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner., Vikis HG, Li W, He Z, Guan KL, Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12457-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11035813 11035813]
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Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho., Driessens MH, Hu H, Nobes CD, Self A, Jordens I, Goodman CS, Hall A, Curr Biol. 2001 Mar 6;11(5):339-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11267870 11267870]
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Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain., Tong Y, Chugha P, Hota PK, Alviani RS, Li M, Tempel W, Shen L, Park HW, Buck M, J Biol Chem. 2007 Dec 21;282(51):37215-24. Epub 2007 Oct 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17916560 17916560]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
 
[[Category: Buck, M.]]
[[Category: Buck, M.]]
[[Category: Tong, Y.]]
[[Category: Tong, Y.]]
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[[Category: Ubiquitin fold]]
[[Category: Ubiquitin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:51:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:42:09 2009''

Revision as of 19:42, 17 February 2009

Image:2jph.png

Template:STRUCTURE 2jph

NMR solution structure of the Rho GTPase binding domain of human plexin-b1

Template:ABSTRACT PUBMED 18275816

About this Structure

2JPH is a 1 chain structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Tong Y, Hota PK, Hamaneh MB, Buck M. Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain. Structure. 2008 Feb;16(2):246-58. PMID:18275816 doi:10.1016/j.str.2007.12.012
  • Tong Y, Hughes D, Placanica L, Buck M. When monomers are preferred: a strategy for the identification and disruption of weakly oligomerized proteins. Structure. 2005 Jan;13(1):7-15. PMID:15642257 doi:10.1016/j.str.2004.10.018
  • Tong Y, Buck M. 1H, 15N and 13C Resonance assignments and secondary structure determination reveal that the minimal Rac1 GTPase binding domain of plexin-B1 has a ubiquitin fold. J Biomol NMR. 2005 Apr;31(4):369-70. PMID:15929008 doi:10.1007/s10858-005-0943-9
  • Oinuma I, Ishikawa Y, Katoh H, Negishi M. The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. Science. 2004 Aug 6;305(5685):862-5. PMID:15297673 doi:10.1126/science.1097545
  • Vikis HG, Li W, He Z, Guan KL. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12457-62. PMID:11035813 doi:10.1073/pnas.220421797
  • Driessens MH, Hu H, Nobes CD, Self A, Jordens I, Goodman CS, Hall A. Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho. Curr Biol. 2001 Mar 6;11(5):339-44. PMID:11267870
  • Tong Y, Chugha P, Hota PK, Alviani RS, Li M, Tempel W, Shen L, Park HW, Buck M. Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. J Biol Chem. 2007 Dec 21;282(51):37215-24. Epub 2007 Oct 4. PMID:17916560 doi:10.1074/jbc.M703800200

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