2r4f

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 23: Line 23:
==About this Structure==
==About this Structure==
-
2R4F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4F OCA].
+
2R4F is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4F OCA].
==Reference==
==Reference==
-
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H -pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia., Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge G, Caspers N, Kowala M, Tait BD, J Med Chem. 2008 Jan 10;51(1):31-45. Epub 2007 Dec 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18072721 18072721]
+
<ref group="xtra">PMID:18072721</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
 
[[Category: Finzel, B C.]]
[[Category: Finzel, B C.]]
[[Category: Harris, M S.]]
[[Category: Harris, M S.]]
Line 51: Line 50:
[[Category: Transmembrane]]
[[Category: Transmembrane]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:58:34 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:32:17 2009''

Revision as of 21:32, 17 February 2009

Image:2r4f.png

Template:STRUCTURE 2r4f

Contents

Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors

Template:ABSTRACT PUBMED 18072721

Disease

Known disease associated with this structure: Statins, attenuated cholesterol lowering by OMIM:[142910]

About this Structure

2R4F is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge G, Caspers N, Kowala M, Tait BD. Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H -pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia. J Med Chem. 2008 Jan 10;51(1):31-45. Epub 2007 Dec 12. PMID:18072721 doi:10.1021/jm070849r

Page seeded by OCA on Tue Feb 17 23:32:17 2009

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2r4f"
Personal tools