2g6w
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(New page: 200px<br /><applet load="2g6w" size="450" color="white" frame="true" align="right" spinBox="true" caption="2g6w, resolution 2.14Å" /> '''Suicide inhibition o...)
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Revision as of 08:52, 21 November 2007
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Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine
Overview
The irreversible inhibition of 8-amino-7-oxononanoate synthase by, trifluoroalanine involves decarboxylative defluorination of the, inhibitor-PLP aldimine followed by attack of the conjugated imine by the, amino group of the active site lysine to afford a covalently bound, difluorinated intermediate which can subsequently undergo further HF, losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl, protein adduct.
About this Structure
2G6W is a Single protein structure of sequence from Escherichia coli with LLF as ligand. Active as 8-amino-7-oxononanoate synthase, with EC number 2.3.1.47 Full crystallographic information is available from OCA.
Reference
Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine., Alexeev D, Baxter RL, Campopiano DJ, Kerbarh O, Sawyer L, Tomczyk N, Watt R, Webster SP, Org Biomol Chem. 2006 Apr 7;4(7):1209-12. Epub 2006 Mar 1. PMID:16557306
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