This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2g6w
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="2g6w" size="450" color="white" frame="true" align="right" spinBox="true" caption="2g6w, resolution 2.14Å" /> '''Suicide inhibition o...)
Next diff →
Revision as of 08:52, 21 November 2007
|
Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine
Overview
The irreversible inhibition of 8-amino-7-oxononanoate synthase by, trifluoroalanine involves decarboxylative defluorination of the, inhibitor-PLP aldimine followed by attack of the conjugated imine by the, amino group of the active site lysine to afford a covalently bound, difluorinated intermediate which can subsequently undergo further HF, losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl, protein adduct.
About this Structure
2G6W is a Single protein structure of sequence from Escherichia coli with LLF as ligand. Active as 8-amino-7-oxononanoate synthase, with EC number 2.3.1.47 Full crystallographic information is available from OCA.
Reference
Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine., Alexeev D, Baxter RL, Campopiano DJ, Kerbarh O, Sawyer L, Tomczyk N, Watt R, Webster SP, Org Biomol Chem. 2006 Apr 7;4(7):1209-12. Epub 2006 Mar 1. PMID:16557306
Page seeded by OCA on Wed Nov 21 11:00:15 2007
