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2g7c
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(New page: 200px<br /><applet load="2g7c" size="450" color="white" frame="true" align="right" spinBox="true" caption="2g7c, resolution 2.0Å" /> '''Clostridium difficile...)
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Revision as of 08:53, 21 November 2007
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Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc
Overview
Clostridium difficile TcdA is a large toxin that binds carbohydrates on, intestinal epithelial cells. A 2-A resolution cocrystal structure reveals, two molecules of, alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in, an extended conformation to TcdA. Residues forming key contacts with the, trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the, rational design of novel therapeutics.
About this Structure
2G7C is a Single protein structure of sequence from Clostridium difficile with GOL as ligand. Full crystallographic information is available from OCA.
Reference
Carbohydrate recognition by Clostridium difficile toxin A., Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK, Nat Struct Mol Biol. 2006 May;13(5):460-1. Epub 2006 Apr 16. PMID:16622409
Page seeded by OCA on Wed Nov 21 11:00:33 2007
