1e3j
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(New page: 200px<br /> <applet load="1e3j" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e3j, resolution 2.30Å" /> '''KETOSE REDUCTASE (S...)
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Revision as of 19:56, 29 October 2007
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KETOSE REDUCTASE (SORBITOL DEHYDROGENASE) FROM SILVERLEAF WHITEFLY
Overview
Polyhydric alcohols are widely found in nature and can be accumulated to, high concentrations as a protection against a variety of environmental, stresses. It is only recently, however, that these molecules have been, shown to be active in protection against heat stress, specifically in the, use of sorbitol by the silverleaf whitefly, Bemisia argentifolii. We have, determined the structure of the enzyme responsible for production of, sorbitol in Bemisia argentifolii, NADP(H)-dependent ketose reductase, (BaKR), to 2.3 A resolution. The structure was solved by multiwavelength, anomalous diffraction (MAD) using the anomalous scattering from two zinc, atoms bound in the structure, and was refined to an R factor of 21.9 %, (R(free)=25.1 %). BaKR belongs to the medium-chain dehydrogenase ... [(full description)]
About this Structure
1E3J is a [Single protein] structure of sequence from [Bemisia argentifolii] with ZN, PO4 and BO3 as [ligands]. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the NADP(H)-dependent ketose reductase from Bemisia argentifolii at 2.3 A resolution., Banfield MJ, Salvucci ME, Baker EN, Smith CA, J Mol Biol. 2001 Feb 16;306(2):239-50. PMID:11237597
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