2gcu

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Revision as of 09:00, 21 November 2007

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spinqualitylabelsall models 2gcu, resolution 1.477Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580

Overview

The protein product of gene At1g53580 from Arabidopsis thaliana possesses, 54% sequence identity to a human enzyme that has been implicated in the, rare disorder ethylmalonic encephalopathy. The structure of the At1g53580, protein has been solved to a nominal resolution of 1.48 Angstrom. This, structure reveals tertiary structure differences between the ETHE1-like, enzyme and glyoxalase II enzymes that are likely to account for, differences in reaction chemistry and multimeric state between the two, types of enzymes. In addition, the Arabidopsis ETHE1 protein is used as a, model to explain the significance of several mutations in the human enzyme, that have been observed in patients with ethylmalonic encephalopathy.

About this Structure

2GCU is a Single protein structure of sequence from Arabidopsis thaliana with FE2, SO4 and EDO as ligands. Active as Hydroxyacylglutathione hydrolase, with EC number 3.1.2.6 Full crystallographic information is available from OCA.

Reference

Structure of an ETHE1-like protein from Arabidopsis thaliana., McCoy JG, Bingman CA, Bitto E, Holdorf MM, Makaroff CA, Phillips GN Jr, Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):964-70. Epub 2006, Aug 19. PMID:16929096

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