2gic
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(New page: 200px<br /><applet load="2gic" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gic, resolution 2.920Å" /> '''Crystal Structure o...)
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Revision as of 09:05, 21 November 2007
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Crystal Structure of a vesicular stomatitis virus nucleocapsid-RNA complex
Overview
Vesicular stomatitis virus is a negative-stranded RNA virus. Its, nucleoprotein (N) binds the viral genomic RNA and is involved in multiple, functions including transcription, replication, and assembly. We have, determined a 2.9 angstrom structure of a complex containing 10 molecules, of the N protein and 90 bases of RNA. The RNA is tightly sequestered in a, cavity at the interface between two lobes of the N protein. This serves to, protect the RNA in the absence of polynucleotide synthesis. For the RNA to, be accessed, some conformational change in the N protein should be, necessary.
About this Structure
2GIC is a Single protein structure of sequence from Vesicular stomatitis indiana virus with IUM as ligand. Full crystallographic information is available from OCA.
Reference
Structure of the vesicular stomatitis virus nucleoprotein-RNA complex., Green TJ, Zhang X, Wertz GW, Luo M, Science. 2006 Jul 21;313(5785):357-60. Epub 2006 Jun 15. PMID:16778022
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