2j8r
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(New page: 200px<br /> <applet load="2j8r" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j8r, resolution 1.55Å" /> '''STRUCTURE OF P. AER...)
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Revision as of 19:58, 29 October 2007
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STRUCTURE OF P. AERUGINOSA ACETYLTRANSFERASE PA4866 SOLVED IN COMPLEX WITH L-METHIONINE SULFOXIMINE
Overview
The gene PA4866 from Pseudomonas aeruginosa is documented in the, Pseudomonas genome database as encoding a 172 amino acid hypothetical, acetyltransferase. We and others have described the 3D structure of this, protein (termed pita) [Davies et al. (2005) Proteins: Struct., Funct., Bioinf. 61, 677-679; Nocek et al., unpublished results], and structures, have also been reported for homologues from Agrobacterium tumefaciens, (Rajashankar et al., unpublished results) and Bacillus subtilis [Badger et, al. (2005) Proteins: Struct., Funct., Bioinf. 60, 787-796]. Pita, homologues are found in a large number of bacterial genomes, and while the, majority of these have been assigned putative phosphinothricin, acetyltransferase activity, their true function is unknown. In this paper, we report that ... [(full description)]
About this Structure
2J8R is a [Single protein] structure of sequence from [Pseudomonas aeruginosa] with AZI, MSL and GOL as [ligands]. Full crystallographic information is available from [OCA].
Reference
l-Methionine sulfoximine, but not phosphinothricin, is a substrate for an acetyltransferase (gene PA4866) from Pseudomonas aeruginosa: structural and functional studies., Davies AM, Tata R, Beavil RL, Sutton BJ, Brown PR, Biochemistry. 2007 Feb 20;46(7):1829-39. Epub 2007 Jan 25. PMID:17253769
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