1ygc
From Proteopedia
(Difference between revisions)
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==About this Structure== | ==About this Structure== | ||
| - | 1YGC is a | + | 1YGC is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YGC OCA]. |
==Reference== | ==Reference== | ||
| - | + | <ref group="xtra">PMID:15632123</ref><references group="xtra"/> | |
[[Category: Coagulation factor VIIa]] | [[Category: Coagulation factor VIIa]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Artis, D R.]] | [[Category: Artis, D R.]] | ||
[[Category: Bunting, S.]] | [[Category: Bunting, S.]] | ||
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[[Category: Inverted oxy-anion hole]] | [[Category: Inverted oxy-anion hole]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:48:39 2009'' |
Revision as of 03:48, 18 February 2009
Contents |
Short Factor VIIa with a small molecule inhibitor
Template:ABSTRACT PUBMED 15632123
Disease
Known disease associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]
About this Structure
1YGC is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Olivero AG, Eigenbrot C, Goldsmith R, Robarge K, Artis DR, Flygare J, Rawson T, Sutherlin DP, Kadkhodayan S, Beresini M, Elliott LO, DeGuzman GG, Banner DW, Ultsch M, Marzec U, Hanson SR, Refino C, Bunting S, Kirchhofer D. A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo. J Biol Chem. 2005 Mar 11;280(10):9160-9. Epub 2005 Jan 4. PMID:15632123 doi:10.1074/jbc.M409068200
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