1gqv
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1gqv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gqv, resolution 0.98Å" /> '''ATOMIC RESOLUTION (...)
Next diff →
Revision as of 20:02, 29 October 2007
|
ATOMIC RESOLUTION (0.98A) STRUCTURE OF EOSINOPHIL-DERIVED NEUROTOXIN
Overview
Human eosinophil-derived neurotoxin (EDN) is a small, basic protein that, belongs to the ribonuclease A superfamily. EDN displays antiviral activity, and causes the neurotoxic Gordon phenomenon when injected into rabbits., Although EDN and ribonuclease A have appreciable structural similarity and, a conserved catalytic triad, their peripheral substrate-binding sites are, not conserved. The crystal structure of recombinant EDN (rEDN) has been, determined at 0.98 A resolution from data collected at a low temperature, (100 K). We have refined the crystallographic model of the structure using, anisotropic displacement parameters to a conventional R-factor of 0.116., This represents the highest resolution structure of rEDN determined to, date and is only the second ribonuclease structure to be ... [(full description)]
About this Structure
1GQV is a [Single protein] structure of sequence from [Homo sapiens] with ACT as [ligand]. Active as [[1]], with EC number [3.1.27.5]. Full crystallographic information is available from [OCA].
Reference
Atomic resolution (0.98 A) structure of eosinophil-derived neurotoxin., Swaminathan GJ, Holloway DE, Veluraja K, Acharya KR, Biochemistry. 2002 Mar 12;41(10):3341-52. PMID:11876642
Page seeded by OCA on Mon Oct 29 22:06:43 2007
