2vm0
From Proteopedia
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{{STRUCTURE_2vm0| PDB=2vm0 | SCENE= }} | {{STRUCTURE_2vm0| PDB=2vm0 | SCENE= }} | ||
| - | + | ===CRYSTAL STRUCTURE OF RADIATION-INDUCED MYOGLOBIN COMPOUND II GENERATED AFTER ANNEALING OF PEROXYMYOGLOBIN=== | |
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| - | ==Overview== | ||
| - | The biological conversions of O(2) and peroxides to water as well as certain incorporations of oxygen atoms into small organic molecules can be catalyzed by metal ions in different clusters or cofactors. The catalytic cycle of these reactions passes through similar metal-based complexes in which one oxygen- or peroxide-derived oxygen atom is coordinated to an oxidized form of the catalytic metal center. In haem-based peroxidases or oxygenases the ferryl (Fe(IV)O) form is important in compound I and compound II, which are two and one oxidation equivalents higher than the ferric (Fe(III)) form, respectively. In this study we report the 1.35 A structure of a compound II model protein, obtained by reacting hydrogen peroxide with ferric myoglobin at pH 5.2. The molecular geometry is virtually unchanged compared to the ferric form, indicating that these reactive intermediates do not undergo large structural changes. It is further suggested that at low pH the dominating compound II resonance form is a hydroxyl radical ferric iron rather than an oxo-ferryl form, based on the short hydrogen bonding to the distal histidine (2.70 A) and the Fe...O distance. The 1.92 A Fe...O distance is in agreement with an EXAFS study of compound II in horseradish peroxidase. | ||
==About this Structure== | ==About this Structure== | ||
| - | 2VM0 is a | + | 2VM0 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM0 OCA]. |
==Reference== | ==Reference== | ||
| - | + | <ref group="xtra">PMID:11935353</ref><references group="xtra"/> | |
[[Category: Equus caballus]] | [[Category: Equus caballus]] | ||
| - | [[Category: Single protein]] | ||
[[Category: Andersson, K K.]] | [[Category: Andersson, K K.]] | ||
[[Category: Gorbitz, C H.]] | [[Category: Gorbitz, C H.]] | ||
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[[Category: Transport]] | [[Category: Transport]] | ||
[[Category: X-ray-induced-photoreduction]] | [[Category: X-ray-induced-photoreduction]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
| + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:50:20 2009'' | ||
Revision as of 06:50, 18 February 2009
CRYSTAL STRUCTURE OF RADIATION-INDUCED MYOGLOBIN COMPOUND II GENERATED AFTER ANNEALING OF PEROXYMYOGLOBIN
About this Structure
2VM0 is a 1 chain structure of sequence from Equus caballus. Full crystallographic information is available from OCA.
Reference
- Hersleth HP, Dalhus B, Gorbitz CH, Andersson KK. An iron hydroxide moiety in the 1.35 A resolution structure of hydrogen peroxide derived myoglobin compound II at pH 5.2. J Biol Inorg Chem. 2002 Mar;7(3):299-304. Epub 2001 Oct 11. PMID:11935353 doi:10.1007/s007750100296
Page seeded by OCA on Wed Feb 18 08:50:20 2009
