2hr6

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==About this Structure==
==About this Structure==
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2HR6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR6 OCA].
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2HR6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR6 OCA].
==Reference==
==Reference==
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Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site., Kovari J, Barabas O, Varga B, Bekesi A, Tolgyesi F, Fidy J, Nagy J, Vertessy BG, Proteins. 2008 Apr;71(1):308-19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17932923 17932923]
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<ref group="xtra">PMID:17932923</ref><ref group="xtra">PMID:15208312</ref><ref group="xtra">PMID:11375495</ref><references group="xtra"/>
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Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase., Barabas O, Pongracz V, Kovari J, Wilmanns M, Vertessy BG, J Biol Chem. 2004 Oct 8;279(41):42907-15. Epub 2004 Jun 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15208312 15208312]
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Atomic resolution structure of Escherichia coli dUTPase determined ab initio., Gonzalez A, Larsson G, Persson R, Cedergren-Zeppezauer E, Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):767-74. Epub 2001, May 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11375495 11375495]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
 
[[Category: DUTP diphosphatase]]
[[Category: DUTP diphosphatase]]
[[Category: Barabas, O.]]
[[Category: Barabas, O.]]
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[[Category: Jelly roll]]
[[Category: Jelly roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:14:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:01:31 2009''

Revision as of 07:01, 18 February 2009

Image:2hr6.png

Template:STRUCTURE 2hr6

Crystal structure of dUTPase in complex with substrate analogue dUDP and manganese

Template:ABSTRACT PUBMED 17932923

About this Structure

2HR6 is a 1 chain structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Kovari J, Barabas O, Varga B, Bekesi A, Tolgyesi F, Fidy J, Nagy J, Vertessy BG. Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site. Proteins. 2008 Apr;71(1):308-19. PMID:17932923 doi:10.1002/prot.21757
  • Barabas O, Pongracz V, Kovari J, Wilmanns M, Vertessy BG. Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase. J Biol Chem. 2004 Oct 8;279(41):42907-15. Epub 2004 Jun 17. PMID:15208312 doi:10.1074/jbc.M406135200
  • Gonzalez A, Larsson G, Persson R, Cedergren-Zeppezauer E. Atomic resolution structure of Escherichia coli dUTPase determined ab initio. Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):767-74. Epub 2001, May 25. PMID:11375495

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