3coh

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(New page: '''Unreleased structure''' The entry 3coh is ON HOLD Authors: Wiesmann, C., Raswson, T.E., Cochran, A.G. Description: Crystal structure of Aurora-A in complex with a pentacyclic inhibi...)
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'''Unreleased structure'''
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{{Seed}}
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[[Image:3coh.jpg|left|200px]]
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The entry 3coh is ON HOLD
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{{STRUCTURE_3coh| PDB=3coh | SCENE= }}
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Authors: Wiesmann, C., Raswson, T.E., Cochran, A.G.
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===Crystal structure of Aurora-A in complex with a pentacyclic inhibitor===
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Description: Crystal structure of Aurora-A in complex with a pentacyclic inhibitor
 
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(as it appears on PubMed at http://www.pubmed.gov), where 18630890 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18630890}}
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 09:33:06 2008''
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==About this Structure==
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3COH is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COH OCA].
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==Reference==
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<ref group="xtra">PMID:18630890</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Cochran, A G.]]
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[[Category: Raswson, T E.]]
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[[Category: Wiesmann, C.]]
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[[Category: Atp-binding]]
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[[Category: Aurora-a]]
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[[Category: Cell cycle]]
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[[Category: Inhibitor complex]]
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[[Category: Kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:07:32 2009''

Revision as of 07:07, 18 February 2009

Template:STRUCTURE 3coh

Crystal structure of Aurora-A in complex with a pentacyclic inhibitor

Template:ABSTRACT PUBMED 18630890

About this Structure

3COH is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Rawson TE, Ruth M, Blackwood E, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Georges GJ, Goller B, Halladay J, Hunsaker T, Kleinheinz T, Krell HW, Li J, Liang J, Limberg A, McNutt A, Moffat J, Phillips G, Ran Y, Safina B, Ultsch M, Walker L, Wiesmann C, Zhang B, Zhou A, Zhu BY, Ruger P, Cochran AG. A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability. J Med Chem. 2008 Aug 14;51(15):4465-75. Epub 2008 Jul 17. PMID:18630890 doi:10.1021/jm800052b

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