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Aconitase

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In most organims, there is a cytosolic enzyme with an ACO domain (cAc), and in eukaryotes, a second copy of it was introduced with mitochondria (mAc). Plants developed even more copies in mitochondria.
In most organims, there is a cytosolic enzyme with an ACO domain (cAc), and in eukaryotes, a second copy of it was introduced with mitochondria (mAc). Plants developed even more copies in mitochondria.
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<applet load='Morph_2ipy-2b3x.pdb.gz' scene='Aconitase/Morph/1' size='400' frame='true' align='right' caption="" />A specialty of cAc is that in mammals it has developed a <scene name='Aconitase/2ipy-total/2'>second function</scene> as inhibitor of <scene name='Aconitase/2ipy-rna/1'>those mRNA</scene> that carry an <scene name='Aconitase/2ipy-rna-ire/1'>iron-regulatory element (IRE)</scene>. Therefore, the cytosolic cAc is named IREBP for IRE-binding protein when this function is talked about. Only one of the two functions is active, depending on whether the (4Fe4S) cofactor is present in the molecule: it's essential for the ACO function. You can see, by <scene name='Aconitase/Morphtest/2'>looking at the morph</scene>, how much the enzyme structure differs between those two functions.
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<applet load='Morph_2ipy-2b3x.pdb.gz' scene='Aconitase/2ipy-total/2' size='400' frame='true' align='right' caption="" />A specialty of cAc is that in mammals it has developed a <scene name='Aconitase/2ipy-total/2'>second function</scene> as inhibitor of <scene name='Aconitase/2ipy-rna/1'>those mRNA</scene> that carry an <scene name='Aconitase/2ipy-rna-ire/1'>iron-regulatory element (IRE)</scene>. Therefore, the cytosolic cAc is named IREBP for IRE-binding protein when this function is talked about. Only one of the two functions is active, depending on whether the (4Fe4S) cofactor is present in the molecule: it's essential for the ACO function. You can see, by <scene name='Aconitase/Morph/1'>looking at the morph</scene>, how much the enzyme structure differs between those two functions.
<!--== Available structures ==
<!--== Available structures ==

Revision as of 10:25, 18 February 2009

Aconitase (ACO) is an enzymatic domain that confers the ability to catalyse the equilibrium

citrate = aconitate + H2O = isocitrate

This reaction is part of the citrate (TCA-, Krebs-)cycle.

In most organims, there is a cytosolic enzyme with an ACO domain (cAc), and in eukaryotes, a second copy of it was introduced with mitochondria (mAc). Plants developed even more copies in mitochondria.

Drag the structure with the mouse to rotate
A specialty of cAc is that in mammals it has developed a as inhibitor of that carry an . Therefore, the cytosolic cAc is named IREBP for IRE-binding protein when this function is talked about. Only one of the two functions is active, depending on whether the (4Fe4S) cofactor is present in the molecule: it's essential for the ACO function. You can see, by , how much the enzyme structure differs between those two functions.

Weblinks

Retrieved from "http://52.214.119.220/wiki/index.php/Aconitase"
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