Sandbox22

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(→Glucokinase)
Line 3: Line 3:
==Glucokinase==
==Glucokinase==
-
Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal saturation curve for its substrate, two properties that are important for its playing the role of a glucose sensor in pancreas and liver. Its structures also revealed an allosteric site through which small molecules may modulate the kinetic properties of the enzyme. This finding provided the mechanistic basis for activation of glucokinase as a potential therapeutic approach for treating type 2 diabetes mellitus.
+
This enzyme facilitates phosphorylation of glucose to glucose-6-phosphate. In humans and most other vertebrates glucokinase is used in teh liver, the pancreas, the gut and brain. It plays an important role in regulating carbohydrate metabolism, triggering shifts in the cell in response to glucose level: glucokinase is a sort of a glucose sensor. It only phosphorylates glucose if its concetnration is high enough. The structure of glucokinase reveals an allosteric site through which small molecules may modulate the kinetic properties of the enzyme; a property that is the basis for using the enzyme when treating type 2 diabetes.
===Structure==={{STRUCTURE_1v4s| PDB=1v4s | SCENE= }}
===Structure==={{STRUCTURE_1v4s| PDB=1v4s | SCENE= }}
Line 16: Line 16:
-
and Matt Joseph Rozin (because he's such a cutie pie)
+
and Matt Joseph Rozin and Gregory Mark Su (because they're so darn cute.)

Revision as of 07:22, 4 March 2009

This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks!

Glucokinase

This enzyme facilitates phosphorylation of glucose to glucose-6-phosphate. In humans and most other vertebrates glucokinase is used in teh liver, the pancreas, the gut and brain. It plays an important role in regulating carbohydrate metabolism, triggering shifts in the cell in response to glucose level: glucokinase is a sort of a glucose sensor. It only phosphorylates glucose if its concetnration is high enough. The structure of glucokinase reveals an allosteric site through which small molecules may modulate the kinetic properties of the enzyme; a property that is the basis for using the enzyme when treating type 2 diabetes.

Structure

PDB ID 1v4s

Drag the structure with the mouse to rotate
1v4s, resolution 2.30Å ()
Ligands: , ,
Activity: Hexokinase, with EC number 2.7.1.1
Related: 1v4t
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


The glucokinase has 18 (unless we counted wrong), 13 (this one is for sure), and 3 : a sodium ion, 2 amino-4-fluoro-5-[(1-methyl-1h-amidazol-2-yl)sulfanyl]-n-(1,3-thiazol-2-yl)benzamide or MRK in short, and last a sugar (alpha-d-glucose) or simply GLC.

Reference

http://www.proteopedia.org/wiki/index.php/1v4s


--Tinuke (Abike etc. etc. etc.) Adeyemi and Niva Ran


and Matt Joseph Rozin and Gregory Mark Su (because they're so darn cute.)

Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox22"
Personal tools