3dds

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Revision as of 12:07, 4 March 2009

Image:3dds.png

Template:STRUCTURE 3dds

Contents

Crystal structure of glycogen phosphorylase complexed with an anthranilimide based inhibitor GSK261

Template:ABSTRACT PUBMED 19138846

Disease

Known disease associated with this structure: Glycogen storage disease VI OMIM:[232700]

About this Structure

3DDS is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Thomson SA, Banker P, Bickett DM, Boucheron JA, Carter HL, Clancy DC, Cooper JP, Dickerson SH, Garrido DM, Nolte RT, Peat AJ, Sheckler LR, Sparks SM, Tavares FX, Wang L, Wang TY, Weiel JE. Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1177-82. Epub 2008 Dec 25. PMID:19138846 doi:10.1016/j.bmcl.2008.12.085

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