2ixq

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Revision as of 10:20, 21 November 2007

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THE SOLUTION STRUCTURE OF THE INVASIVE TIP COMPLEX FROM AFA-DR FIBRILS

Overview

Afa/Dr family of adhesins are produced by pathogenic Escherichia coli, strains that are especially prevalent in chronic diarrhoeal and recurrent, urinary tract infections. Most notably, they are found in up to 50% of, cystitis cases in children and 30% of pyelonephritis in pregnant women., Afa/Dr adhesins are capped surface fibrils that mediate recognition of the, host and subsequent bacterial internalization. Using the newly solved, three-dimensional structure of the minimal invasive complex (AfaDE), combined with biochemical and cellular assays, we reveal the architecture, of the fibrillar cap and identify a novel mode of synergistic integrin, recognition.

About this Structure

2IXQ is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

The solution structure of the invasive tip complex from Afa/Dr fibrils., Cota E, Jones C, Simpson P, Altroff H, Anderson KL, du Merle L, Guignot J, Servin A, Le Bouguenec C, Mardon H, Matthews S, Mol Microbiol. 2006 Oct;62(2):356-66. Epub 2006 Sep 8. PMID:16965519

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