3cde

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3cde.jpg|left|200px]]
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The entry 3cde is ON HOLD until Feb 26 2010
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{{STRUCTURE_3cde| PDB=3cde | SCENE= }}
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Authors: Zhao, Q., Showalter, R.E., Han, Q., Kissinger, C.R.
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===Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor===
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Description: Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 13:03:37 2008''
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{{ABSTRACT_PUBMED_18457949}}
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==About this Structure==
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3CDE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDE OCA].
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==Reference==
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<ref group="xtra">PMID:18457949</ref><references group="xtra"/>
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[[Category: Hepatitis c virus]]
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Han, Q.]]
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[[Category: Kissinger, C R.]]
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[[Category: Showalter, R E.]]
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[[Category: Zhao, Q.]]
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[[Category: Atp-binding]]
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[[Category: Host-virus interaction]]
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[[Category: Hydrolase]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Protein-ligand complex]]
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[[Category: Ribonucleoprotein]]
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[[Category: Rna replication]]
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[[Category: Rna-binding]]
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[[Category: Rna-directed rna polymerase]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transferase]]
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[[Category: Viral nucleoprotein]]
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[[Category: Virion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 4 14:41:36 2009''

Revision as of 12:41, 4 March 2009

Image:3cde.jpg

Template:STRUCTURE 3cde

Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor

Template:ABSTRACT PUBMED 18457949

About this Structure

3CDE is a 2 chains structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

  • Li LS, Zhou Y, Murphy DE, Stankovic N, Zhao J, Dragovich PS, Bertolini T, Sun Z, Ayida B, Tran CV, Ruebsam F, Webber SE, Shah AM, Tsan M, Showalter RE, Patel R, Lebrun LA, Bartkowski DM, Nolan TG, Norris DA, Kamran R, Brooks J, Sergeeva MV, Kirkovsky L, Zhao Q, Kissinger CR. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)- 5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3446-55. Epub 2008 Mar 5. PMID:18457949 doi:10.1016/j.bmcl.2008.02.072

Page seeded by OCA on Wed Mar 4 14:41:36 2009

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