2jm6

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Revision as of 10:30, 21 November 2007

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Solution structure of MCL-1 complexed with NOXAB

Overview

Apoptosis is held in check by prosurvival proteins of the Bcl-2 family., The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa, to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding, of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We, compared the three-dimensional structures of the complexes formed between, BH3 peptides of both Bim and Noxa, and we show that a discrete C-terminal, sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation.

About this Structure

2JM6 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural insights into the degradation of Mcl-1 induced by BH3 domains., Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DC, Fairlie WD, Hinds MG, Colman PM, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. Epub 2007 Mar 27. PMID:17389404

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