3frz

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3frz.jpg|left|200px]]
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The entry 3frz is ON HOLD
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{{STRUCTURE_3frz| PDB=3frz | SCENE= }}
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Authors: Parge, H.E.
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===Crystal Structure of HCV NS5B RNA polymerase in complex with PF868554===
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Description: Crystal Structure of HCV NS5B RNA polymerase in complex with PF868554
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 11 11:10:29 2009''
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{{ABSTRACT_PUBMED_19209845}}
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==About this Structure==
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3FRZ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FRZ OCA].
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==Reference==
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<ref group="xtra">PMID:19209845</ref><references group="xtra"/>
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[[Category: Hepatitis c virus]]
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Parge, H E.]]
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[[Category: Acetylation]]
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[[Category: Apoptosis]]
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[[Category: Atp-binding]]
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[[Category: Capsid protein]]
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[[Category: Cell membrane]]
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[[Category: Cytoplasm]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Envelope protein]]
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[[Category: Fusion protein]]
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[[Category: Glycoprotein]]
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[[Category: Helicase]]
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[[Category: Host-virus interaction]]
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[[Category: Hydrolase]]
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[[Category: Interferon antiviral system evasion]]
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[[Category: Lipid droplet]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Mitochondrion]]
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[[Category: Multifunctional enzyme]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Nucleus]]
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[[Category: Oncogene]]
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[[Category: Palmitate]]
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[[Category: Phosphoprotein]]
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[[Category: Protease]]
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[[Category: Ribonucleoprotein]]
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[[Category: Rna replication]]
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[[Category: Rna-binding]]
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[[Category: Rna-directed rna polymerase]]
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[[Category: Secreted]]
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[[Category: Serine protease]]
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[[Category: Sh3-binding]]
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[[Category: Thiol protease]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transferase]]
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[[Category: Transmembrane]]
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[[Category: Ubl conjugation]]
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[[Category: Viral nucleoprotein]]
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[[Category: Viral polymerase]]
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[[Category: Virion]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 11 11:17:31 2009''

Revision as of 09:17, 11 March 2009

Image:3frz.jpg

Template:STRUCTURE 3frz

Crystal Structure of HCV NS5B RNA polymerase in complex with PF868554

Template:ABSTRACT PUBMED 19209845

About this Structure

3FRZ is a 1 chain structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

  • Li H, Tatlock J, Linton A, Gonzalez J, Jewell T, Patel L, Ludlum S, Drowns M, Rahavendran SV, Skor H, Hunter R, Shi ST, Herlihy KJ, Parge H, Hickey M, Yu X, Chau F, Nonomiya J, Lewis C. Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1 ,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-on e (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor. J Med Chem. 2009 Feb 11. PMID:19209845 doi:10.1021/jm8014537

Page seeded by OCA on Wed Mar 11 11:17:31 2009

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