1ayo

From Proteopedia

Revision as of 20:07, 29 October 2007

RECEPTOR BINDING DOMAIN OF BOVINE ALPHA-2-MACROGLOBULIN

Overview

BACKGROUND: The large plasma proteinase inhibitors of the alpha, 2-macroglobulin superfamily inhibit proteinases by capturing them within a, central cavity of the inhibitor molecule. After reaction with the, proteinase, the alpha-macroglobulin-proteinase complex binds to the, alpha-macroglobulin receptor, present in the liver and other tissues, and, becomes endocytosed and rapidly removed from the circulation. The complex, binds to the receptor via recognition sites located on a separate domain, of approximately 138 residues positioned at the C terminus of the, alpha-macroglobulin subunit. RESULTS: The crystal structure of the, receptor-binding domain of bovine alpha 2-macroglobulin (bRBD) has been, determined at a resolution of 1.9 A. The domain primarily comprises a, nine-strand beta ... [(full description)]

About this Structure

1AYO is a [Single protein] structure of sequence from [Bos taurus] with CA as [ligand]. Full crystallographic information is available from [OCA].

Reference

Crystal structure of the receptor-binding domain of alpha 2-macroglobulin., Jenner L, Husted L, Thirup S, Sottrup-Jensen L, Nyborg J, Structure. 1998 May 15;6(5):595-604. PMID:9634697

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