Triose Phosphate Isomerase
From Proteopedia
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| - | '''Triose Phosphate Isomerase''' | + | '''Triose Phosphate Isomerase''' |
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{{STRUCTURE_1tim | PDB=1tim | SCENE= }} | {{STRUCTURE_1tim | PDB=1tim | SCENE= }} | ||
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| + | == Overview == | ||
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| + | (TPI or TIM) which catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate, an essential process in the glycolytic pathway. | ||
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== Mechanism == | == Mechanism == | ||
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| + | TPI catalyzes the transfer of a hydrogen atom from carbon 1 to carbon 2, an intramolecular oxidation-reduction. This isomerization of a ketose to an aldose proceeds through an enediol intermediate.<Biochemistry 6th Edition> | ||
=== Acid Base Catalysis === | === Acid Base Catalysis === | ||
Revision as of 13:59, 19 March 2009
Triose Phosphate Isomerase
Contents |
Overview
(TPI or TIM) which catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate, an essential process in the glycolytic pathway.
Mechanism
TPI catalyzes the transfer of a hydrogen atom from carbon 1 to carbon 2, an intramolecular oxidation-reduction. This isomerization of a ketose to an aldose proceeds through an enediol intermediate.<Biochemistry 6th Edition>
Acid Base Catalysis
Diagram .<ref name= "web.virginia.edu" [1]
Structure & Function
Disease
Triose Phosphate Isomerase Deficiency
See Also
References For further information on Triose Phosphate Isomerase
Proteopedia Page Contributors and Editors (what is this?)
Gregg Snider, Eric Martz, Michal Harel, Alexander Berchansky, David Canner, Eran Hodis, Stephen Everse, Angel Herraez, Jane S. Richardson
![[1]](http://web.virginia.edu/Heidi/chapter19/Images/8883n19_15.jpg){kind=link}