Triose Phosphate Isomerase

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	'''Triose Phosphate Isomerase'''		'''Triose Phosphate Isomerase'''
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Revision as of 14:08, 19 March 2009

Triose Phosphate Isomerase

Image:TPIstructure.gif

Template:STRUCTURE 1tim

Contents 1 Overview 2 Mechanism 2.1 Acid Base Catalysis 3 Structure & Function 4 Disease 4.1 Triose Phosphate Isomerase Deficiency 5 See Also 6 References For further information on Triose Phosphate Isomerase

Overview

(TPI or TIM) which catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate, an essential process in the glycolytic pathway.

Mechanism

TPI catalyzes the transfer of a hydrogen atom from carbon 1 to carbon 2, an intramolecular oxidation-reduction. This isomerization of a ketose to an aldose proceeds through an enediol intermediate.<Biochemistry 6th Edition>

Acid Base Catalysis

Image:TPI mechanism.jpg

Diagram .<ref name= "web.virginia.edu" [1]

Structure & Function

Disease

Triose Phosphate Isomerase Deficiency

See Also

References For further information on Triose Phosphate Isomerase

Berg, Jeremy M. Sryer, Lubert. Tymoczko, John L. Biochemistry: 6th Edition. W.H Freedman and Company (2007)