2cky

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(New page: 200px<br /> <applet load="2cky" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cky, resolution 2.90&Aring;" /> '''Structure of the ar...)
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Revision as of 20:09, 29 October 2007

Image:2cky.gif

2cky, resolution 2.90Å

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Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand

Overview

Riboswitches are untranslated regions of messenger RNA, which adopt, alternate structures depending on the binding of specific metabolites., Such conformational switching regulates the expression of proteins, involved in the biosynthesis of riboswitch substrates. Here, we present, the 2.9 angstrom-resolution crystal structure of the eukaryotic, Arabidopsis thaliana thiamine pyrophosphate (TPP)-specific riboswitch in, complex with its natural ligand. The riboswitch specifically recognizes, the TPP via conserved residues located within two highly distorted, parallel "sensor" helices. The structure provides the basis for, understanding the reorganization of the riboswitch fold upon TPP binding, and explains the mechanism of resistance to the antibiotic pyrithiamine.

About this Structure

2CKY is a [Single protein] structure of sequence from [[1]] with MG, OS and TPP as [ligands]. Full crystallographic information is available from [OCA].

Reference

Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand., Thore S, Leibundgut M, Ban N, Science. 2006 May 26;312(5777):1208-11. Epub 2006 May 4. PMID:16675665

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