3fl0

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3fl0.jpg|left|200px]]
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The entry 3fl0 is ON HOLD until Paper Publication
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{{STRUCTURE_3fl0| PDB=3fl0 | SCENE= }}
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Authors: Merlino, A., Russo Krauss, I., Perillo, M., Mattia, C.A., Ercole, C., Picone, D., Vergara, A., Sica, F.
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===X-ray structure of the non covalent swapped form of the Q28L/K31C/S32C mutant of bovine pancreatic ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE===
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Description: X-ray structure of the non covalent swapped form of the Q28L/K31C/S32C mutant of bovine pancreatic ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 7 09:35:27 2009''
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(as it appears on PubMed at http://www.pubmed.gov), where 19280639 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19280639}}
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==About this Structure==
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3FL0 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FL0 OCA].
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==Reference==
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<ref group="xtra">PMID:19280639</ref><ref group="xtra">PMID:15192098</ref><ref group="xtra">PMID:18164315</ref><ref group="xtra">PMID:8520472</ref><references group="xtra"/>
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[[Category: Bos taurus]]
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[[Category: Pancreatic ribonuclease]]
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[[Category: Ercole, C.]]
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[[Category: Krauss, I Russo.]]
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[[Category: Mattia, C A.]]
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[[Category: Merlino, A.]]
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[[Category: Perillo, M.]]
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[[Category: Picone, D.]]
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[[Category: Sica, F.]]
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[[Category: Vergara, A.]]
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[[Category: 3d-domain swapping]]
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[[Category: Antitumor activity]]
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[[Category: Bovine seminal ribonuclease]]
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[[Category: Endonuclease]]
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[[Category: Glycation]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Non-covalent dimer]]
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[[Category: Nuclease]]
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[[Category: Protein mutations and evolution]]
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[[Category: Quaternary structure flexibility]]
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[[Category: Secreted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 25 12:31:13 2009''

Revision as of 10:31, 25 March 2009

Image:3fl0.jpg

Template:STRUCTURE 3fl0

X-ray structure of the non covalent swapped form of the Q28L/K31C/S32C mutant of bovine pancreatic ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE

Template:ABSTRACT PUBMED 19280639

About this Structure

3FL0 is a 2 chains structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Merlino A, Krauss IR, Perillo M, Mattia CA, Ercole C, Picone D, Vergara A, Sica F. Towards an antitumor form of bovine pancreatic ribonuclease: The crystal structure of three non-covalent dimeric mutants. Biopolymers. 2009 Mar 11. PMID:19280639 doi:10.1002/bip.21183
  • Sica F, Di Fiore A, Merlino A, Mazzarella L. Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease: an enzyme tailored to evade ribonuclease protein inhibitor. J Biol Chem. 2004 Aug 27;279(35):36753-60. Epub 2004 Jun 9. PMID:15192098 doi:http://dx.doi.org/10.1074/jbc.M405655200
  • Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F. The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme. J Mol Biol. 2008 Feb 15;376(2):427-37. Epub 2007 Nov 12. PMID:18164315 doi:http://dx.doi.org/10.1016/j.jmb.2007.11.008
  • Di Donato A, Cafaro V, Romeo I, D'Alessio G. Hints on the evolutionary design of a dimeric RNase with special bioactions. Protein Sci. 1995 Aug;4(8):1470-7. PMID:8520472 doi:http://dx.doi.org/10.1002/pro.5560040804

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