2w3k

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(New page: '''Unreleased structure''' The entry 2w3k is ON HOLD Authors: Zhang, E., Mochalkin, I., Casimiro-Garcia, A., Van Huis, C. Description: Crystal Structure of FXa in complex with 4,4-disu...)
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'''Unreleased structure'''
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{{Seed}}
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[[Image:2w3k.jpg|left|200px]]
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The entry 2w3k is ON HOLD
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{{STRUCTURE_2w3k| PDB=2w3k | SCENE= }}
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Authors: Zhang, E., Mochalkin, I., Casimiro-Garcia, A., Van Huis, C.
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===CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 4,4-DISUBSTITUTED PYRROLIDINE-1,2-DICARBOXAMIDE INHIBITOR 1===
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Description: Crystal Structure of FXa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 1
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 20 07:35:32 2008''
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{{ABSTRACT_PUBMED_19231206}}
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==About this Structure==
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2W3K is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3K OCA].
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==Reference==
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<ref group="xtra">PMID:19231206</ref><references group="xtra"/>
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[[Category: Coagulation factor Xa]]
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[[Category: Homo sapiens]]
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[[Category: Casimiro-Garcia, A.]]
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[[Category: Huis, C A.Van.]]
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[[Category: Mochalkin, I.]]
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[[Category: Zhang, E.]]
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[[Category: Blood clotting]]
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[[Category: Blood coagulation]]
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[[Category: Calcium]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Drug design]]
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[[Category: Egf-like domain]]
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[[Category: Fxa coagulation factor inhibitor]]
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[[Category: Gamma-carboxyglutamic acid]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Hydroxylation]]
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[[Category: Polymorphism]]
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[[Category: Protease]]
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[[Category: Secreted]]
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[[Category: Serine protease]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 9 12:18:33 2009''

Revision as of 09:18, 9 April 2009

Image:2w3k.jpg

Template:STRUCTURE 2w3k

CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 4,4-DISUBSTITUTED PYRROLIDINE-1,2-DICARBOXAMIDE INHIBITOR 1

Template:ABSTRACT PUBMED 19231206

About this Structure

2W3K is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Van Huis CA, Casimiro-Garcia A, Bigge CF, Cody WL, Dudley DA, Filipski KJ, Heemstra RJ, Kohrt JT, Leadley RJ Jr, Narasimhan LS, McClanahan T, Mochalkin I, Pamment M, Peterson JT, Sahasrabudhe V, Schaum RP, Edmunds JJ. Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action. Bioorg Med Chem. 2009 Mar 15;17(6):2501-11. Epub 2009 Feb 3. PMID:19231206 doi:10.1016/j.bmc.2009.01.063

Page seeded by OCA on Thu Apr 9 12:18:33 2009

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