2fvc
From Proteopedia
(Difference between revisions)
| Line 30: | Line 30: | ||
[[Category: Hcv polymerase]] | [[Category: Hcv polymerase]] | ||
[[Category: Thiadiazin inhibitor]] | [[Category: Thiadiazin inhibitor]] | ||
| + | [[Category: Transferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:13:01 2009'' |
Revision as of 06:13, 15 April 2009
Crystal structure of NS5B BK strain (delta 24) in complex with a 3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinone
Template:ABSTRACT PUBMED 16451063
About this Structure
2FVC is a 2 chains structure of sequences from Hepatitis c virus subtype 1b. Full crystallographic information is available from OCA.
Reference
- Tedesco R, Shaw AN, Bambal R, Chai D, Concha NO, Darcy MG, Dhanak D, Fitch DM, Gates A, Gerhardt WG, Halegoua DL, Han C, Hofmann GA, Johnston VK, Kaura AC, Liu N, Keenan RM, Lin-Goerke J, Sarisky RT, Wiggall KJ, Zimmerman MN, Duffy KJ. 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones , potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem. 2006 Feb 9;49(3):971-83. PMID:16451063 doi:10.1021/jm050855s
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