2z9q
From Proteopedia
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{{STRUCTURE_2z9q| PDB=2z9q | SCENE= }} | {{STRUCTURE_2z9q| PDB=2z9q | SCENE= }} | ||
| - | + | ===Transfer RNA in the hybrid P/E state=== | |
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| - | ==Overview== | ||
| - | During the ribosomal translocation, the binding of elongation factor G (EF-G) to the pretranslocational ribosome leads to a ratchet-like rotation of the 30S subunit relative to the 50S subunit in the direction of the mRNA movement. By means of cryo-electron microscopy we observe that this rotation is accompanied by a 20 A movement of the L1 stalk of the 50S subunit, implying that this region is involved in the translocation of deacylated tRNAs from the P to the E site. These ribosomal motions can occur only when the P-site tRNA is deacylated. Prior to peptidyl-transfer to the A-site tRNA or peptide removal, the presence of the charged P-site tRNA locks the ribosome and prohibits both of these motions. | ||
==About this Structure== | ==About this Structure== | ||
| - | 2Z9Q is a | + | 2Z9Q is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9Q OCA]. |
==Reference== | ==Reference== | ||
| - | + | <ref group="xtra">PMID:12859903</ref><references group="xtra"/> | |
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[[Category: Thermus aquaticus]] | [[Category: Thermus aquaticus]] | ||
[[Category: Frank, J.]] | [[Category: Frank, J.]] | ||
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[[Category: Rna]] | [[Category: Rna]] | ||
[[Category: Twisted cca arm]] | [[Category: Twisted cca arm]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
| + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:26:10 2009'' | ||
Revision as of 06:26, 15 April 2009
Transfer RNA in the hybrid P/E state
About this Structure
2Z9Q is a 1 chain structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.
Reference
- Valle M, Zavialov A, Sengupta J, Rawat U, Ehrenberg M, Frank J. Locking and unlocking of ribosomal motions. Cell. 2003 Jul 11;114(1):123-34. PMID:12859903
Page seeded by OCA on Wed Apr 15 09:26:10 2009
