User:Karl E. Zahn/Sandbox RB69 1/domain-structure
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(New page: DNA polymerases (pols) are a specialized class of transferase enzymes that catalyze template directed extension of a primed DNA. The family B DNA pol encoded in the genome of the bacterio...)
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Revision as of 20:18, 16 April 2009
DNA polymerases (pols) are a specialized class of transferase enzymes that catalyze template directed extension of a primed DNA. The family B DNA pol encoded in the genome of the bacteriophage RB69 represents such an enzyme that shares significant homology with the human primase associated pol α, the human replicative pol δ and ε, and the human repair pol ζ. When considered in light of the relative ease with which RB69 pol can form diffraction quality crystals in complex with DNA, this enzyme has been the focus of many biochemical and structural studies that aim to reveal details of DNA replication in humans.
