NS5B

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	The template strand is seen entering through a gap in the fingers domain, incoming nucleotide that extends the primer lines up with the NS5B active site and duplex DNA exits the enzyme through the large central hole.		The template strand is seen entering through a gap in the fingers domain, incoming nucleotide that extends the primer lines up with the NS5B active site and duplex DNA exits the enzyme through the large central hole.
-	[[Image:NS5B_RNA_binders.jpg]]	+	[[Image:2HAI_RNA_binders.jpg]]
	== ''NS5B with peptide segments known to bind RNA highlighted'' ==		== ''NS5B with peptide segments known to bind RNA highlighted'' ==

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Revision as of 07:17, 20 April 2009

RNA Dependent RNA Polymerase from Hepatitis C Virus

spinqualitylabelsall models PDB ID 2HAI Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Placeholder, type here.

Image:2HAI domains.jpg

NS5B with active site carboxylates highlighted

spinqualitylabelsall models PDB IDs 2HAI (protein) 1RTD (DNA) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

NS5B with B form DNA from HIV Reverse Transcriptase co-crystal model. DNA was modeled in by alignment of palms domain. A beta hairpin in the thumb domain has been moved to accommodate DNA, the hairpin is modeled into the minor groove, a possible binding site. Catalytic Mg2+ ions are modeled in green, these would be coordinated by the three aspartic acid carboxylates, (D220, D318 and D319).

The template strand is seen entering through a gap in the fingers domain, incoming nucleotide that extends the primer lines up with the NS5B active site and duplex DNA exits the enzyme through the large central hole.

Image:2HAI RNA binders.jpg

NS5B with peptide segments known to bind RNA highlighted

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Image:PolyProtein.jpg