2tss
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(New page: 200px<br /><applet load="2tss" size="450" color="white" frame="true" align="right" spinBox="true" caption="2tss, resolution 2.05Å" /> '''TOXIC SHOCK SYNDROME...)
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Revision as of 11:59, 21 November 2007
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TOXIC SHOCK SYNDROME TOXIN-1 FROM STAPHYLOCOCCUS AUREUS: ORTHORHOMBICC222(1) CRYSTAL FORM
Overview
The structure of toxic shock syndrome toxin-1 (TSST-1), the causative, agent in toxic shock syndrome, has been determined in three crystal forms., The three structural models have been refined to R-factors of 0.154, 0.150, and 0.198 at resolutions of 2.05 A, 2.90 A, and 2.75 A, respectively. One crystal form of TSST-1 contains a zinc ion bound between, two symmetry-related molecules. Although not required for biological, activity, zinc dramatically potentiates the mitogenicity of TSST-1 at very, low concentrations. In addition, the structure of the tetramutant TSST-1H, [T69I, Y80W, E132K, I140T], which is nonmitogenic and does not amplify, endotoxin shock, has been determined and refined in a fourth crystal form, (R-factor = 0.173 to 1.9 A resolution).
About this Structure
2TSS is a Single protein structure of sequence from Staphylococcus aureus. This structure superseeds the now removed PDB entry 1TSS. Full crystallographic information is available from OCA.
Reference
Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity., Prasad GS, Radhakrishnan R, Mitchell DT, Earhart CA, Dinges MM, Cook WJ, Schlievert PM, Ohlendorf DH, Protein Sci. 1997 Jun;6(6):1220-7. PMID:9194182
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