2v8o

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(New page: 200px<br /><applet load="2v8o" size="450" color="white" frame="true" align="right" spinBox="true" caption="2v8o, resolution 1.90&Aring;" /> '''STRUCTURE OF THE MUR...)
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Revision as of 12:05, 21 November 2007

Image:2v8o.gif

2v8o, resolution 1.90Å

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STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS RNA HELICASE TO 1.9A RESOLUTION

Overview

Murray Valley encephalitis virus (MVEV), a mosquito-borne flavivirus, endemic to Australia, is closely related to Japanese encephalitis virus, and West Nile virus. Nonstructural protein 3 (NS3) is a multifunctional, enzyme with serine protease and DEXH/D-box helicase domains, whose, activity is central to flavivirus replication and is therefore a possible, target for anti-flaviviral compounds. Cloning, purification, and crystal, structure determination to 1.9 A resolution of the NS3 helicase of MVEV, and characterization of its enzymatic activity is reported. Comparison, with the structures of helicases from related viruses supports a possible, mechanism of ATP hydrolysis-driven strand separation.

About this Structure

2V8O is a Single protein structure of sequence from Murray valley encephalitis virus. Active as Flavivirin, with EC number 3.4.21.91 Full crystallographic information is available from OCA.

Reference

Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 A resolution., Mancini EJ, Assenberg R, Verma A, Walter TS, Tuma R, Grimes JM, Owens RJ, Stuart DI, Protein Sci. 2007 Oct;16(10):2294-300. PMID:17893366

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