1ic9

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Revision as of 19:38, 24 November 2007

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NMR SOLUTION STRUCTURE OF THE DESIGNED BETA-SHEET MINI-PROTEIN TH10AOX

Overview

Here we report the creation of a predominantly beta-structured, mini-protein motif. The design target is based on the naturally occurring, toxin hand (TH) motifs that are composed of four disulfide bonds and three, loops that form a 'hand'. Analysis and subsequent modification of several, generations of mini-proteins produced the final 29-residue mini-protein., The structured motif of this new mini-protein provides insight into the, compensatory changes that result in the formation of a tightly packed, hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein, design and a valuable, yet compact, model system for the study of, beta-sheet structure in water.

About this Structure

1IC9 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:11373623

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