X-ray crystallography
From Proteopedia
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*[http://en.wikipedia.org/wiki/X-ray_crystallography X-ray Crystallography at Wikipedia] | *[http://en.wikipedia.org/wiki/X-ray_crystallography X-ray Crystallography at Wikipedia] | ||
*[http://hamptonresearch.com/gallery.aspx Protein Crystal Gallery] | *[http://hamptonresearch.com/gallery.aspx Protein Crystal Gallery] | ||
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*[[Quality assessment for molecular models]] | *[[Quality assessment for molecular models]] | ||
Revision as of 00:24, 19 May 2009
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| Flow chart showing the major steps in X-ray protein crystallography. (Image from Wikimedia courtesy Thomas Splettstoesser. |
About 85% of the models (entries) in the World Wide Protein Data Bank were determined by X-ray crystallography. (Most of the remaining 15% were determined by solution nuclear magnetic resonance.) Protein crystallography remains very difficult, despite many recent advances. For every new protein sequence targeted for X-ray crystallography, about one in twenty is solved[1][2]. Publication of solved structures involves depositing an atomic coordinate file (PDB file) in the World Wide Protein Data Bank.
See Also
Further Reading
- Crystallography Made Crystal Clear: a guide for users of macromolecular models, a book by Gale Rhodes.
