1e4h
From Proteopedia
(New page: 200px<br /> <applet load="1e4h" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e4h, resolution 1.8Å" /> '''STRUCTURE OF HUMAN T...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1E4H is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with PBR and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E4H OCA]]. | + | 1E4H is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with PBR and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: AC1 and AC2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E4H OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: transport(thyroxine)]] | [[Category: transport(thyroxine)]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:22:02 2007'' |
Revision as of 06:17, 30 October 2007
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STRUCTURE OF HUMAN TRANSTHYRETIN COMPLEXED WITH BROMOPHENOLS: A NEW MODE OF BINDING
Overview
The binding of two organohalogen substances, pentabromophenol (PBP) and, 2,4,6-tribromophenol (TBP), to human transthyretin (TTR), a thyroid, hormone transport protein, has been studied by in vitro competitive, binding assays and by X-ray crystallography. Both compounds bind to TTR, with high affinity, in competition with the natural ligand thyroxine, (T(4)). The crystal structures of the TTR-PBP and TTR-TBP complexes show, some unusual binding patterns for the ligands. They bind exclusively in, the 'reversed' mode, with their hydroxyl group pointing towards the mouth, of the binding channel and in planes approximately perpendicular to that, adopted by the T(4) phenolic ring in a TTR-T(4) complex, a feature not, observed before. The hydroxyl group in the ligands, which was previously, ... [(full description)]
About this Structure
1E4H is a [Single protein] structure of sequence from [Homo sapiens] with PBR and GOL as [ligands]. Structure known Active Sites: AC1 and AC2. Full crystallographic information is available from [OCA].
Reference
Structure of human transthyretin complexed with bromophenols: a new mode of binding., Ghosh M, Meerts IA, Cook A, Bergman A, Brouwer A, Johnson LN, Acta Crystallogr D Biol Crystallogr. 2000 Sep;56(Pt 9):1085-95. PMID:10957627
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