176d

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Revision as of 19:58, 24 November 2007

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NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA

Overview

Peptide nucleic acids (PNA) incorporating nucleic acid bases into an, achiral polyamide backbone bind to DNA in a sequence-dependent manner. The, structure of a PNA-ribonucleic acid (RNA) complex was determined with, nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex, with a complementary RNA that is an antiparallel, right-handed double, helix with Watson-Crick base pairing similar to the "A" form structure of, RNA duplexes. The achiral PNA backbone assumed a distinct conformation, upon binding that differed from previously proposed models and provides a, basis for further structure-based design of antisense agents.

About this Structure

176D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

NMR solution structure of a peptide nucleic acid complexed with RNA., Brown SC, Thomson SA, Veal JM, Davis DG, Science. 1994 Aug 5;265(5173):777-80. PMID:7519361

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