1jlm
From Proteopedia
(New page: 200px<br /> <applet load="1jlm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jlm, resolution 2.0Å" /> '''I-DOMAIN FROM INTEGR...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1JLM is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JLM OCA]]. | + | 1JLM is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: MN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JLM OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: integrin]] | [[Category: integrin]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:23:14 2007'' |
Revision as of 06:18, 30 October 2007
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I-DOMAIN FROM INTEGRIN CR3, MN2+ BOUND
Overview
BACKGROUND: Integrins are plasma membrane proteins that mediate adhesion, to other cells and to components of the extracellular matrix. Most, integrins are constitutively inactive in resting cells, but are rapidly, and reversibly activated in response to agonists, leading to highly, regulated cell adhesion. This activation is associated with conformational, changes in their extracellular portions, but the nature of the structural, changes that lead to a change in adhesiveness is not understood. The, interactions of several integrins with their extracellular ligands are, mediated by an A-type domain (generally called the I-domain in integrins)., Binding of the I-domain to protein ligands is dependent on divalent, cations. We have described previously the structure of the I-domain from, ... [(full description)]
About this Structure
1JLM is a [Single protein] structure of sequence from [Homo sapiens] with MN as [ligand]. Structure known Active Site: MN. Full crystallographic information is available from [OCA].
Reference
Two conformations of the integrin A-domain (I-domain): a pathway for activation?, Lee JO, Bankston LA, Arnaout MA, Liddington RC, Structure. 1995 Dec 15;3(12):1333-40. PMID:8747460
Page seeded by OCA on Tue Oct 30 08:23:14 2007
