1r8i

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(New page: 200px<br /><applet load="1r8i" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r8i, resolution 3.00&Aring;" /> '''Crystal structure of...)
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Revision as of 20:13, 24 November 2007

Image:1r8i.jpg

1r8i, resolution 3.00Å

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Crystal structure of TraC

Overview

Type IV secretion systems mediate intercellular transfer of, macro-molecules via a mechanism ancestrally related to that of bacterial, conjugation machineries. TraC of the IncN plasmid pKM101 belongs to the, VirB5 family of proteins, an essential component of most type IV secretion, systems. Here, we present the structure of TraC. VirB5/TraC is a single, domain protein, which consists of a three helix bundle and a loose, globular appendage. Structure-based site-directed mutagenesis followed by, functional studies indicates that VirB5 proteins participate in, protein-protein interactions important for pilus assembly and function.

About this Structure

1R8I is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural and functional characterization of the VirB5 protein from the type IV secretion system encoded by the conjugative plasmid pKM101., Yeo HJ, Yuan Q, Beck MR, Baron C, Waksman G, Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15947-52. Epub 2003 Dec 12. PMID:14673074

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