1r8o
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(New page: 200px<br /><applet load="1r8o" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r8o, resolution 1.83Å" /> '''Crystal structure of...)
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Revision as of 20:14, 24 November 2007
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Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds
Overview
The crystallographic structure of a novel trypsin inhibitor (CTI) from, Copaifera langsdorffii is reported. The structure was solved by MIRAS, procedure and refined to a crystallographic residual of 17.3% (R(free) =, 20.3%) at 1.8 A resolution. Two isomorphous derivatives were obtained by, quick cryo-soaking approach. CTI is the first structure of a member of, Kunitz (STI) family formed by two noncovalently bound polypeptide chains, and only one disulfide bridge. A standard Kunitz-type inhibitor has a, single polypeptide chain and two disulfide bridges. Structural features, granting CTI high inhibitory activity are discussed.
About this Structure
1R8O is a Protein complex structure of sequences from Copaifera langsdorffii. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of an unusual Kunitz (STI) type trypsin inhibitor from Copaifera langsdorffii., Krauchenco S, Nagem RA, da Silva JA, Marangoni S, Polikarpov I, Biochimie. 2004 Mar;86(3):167-72. PMID:15134830
Page seeded by OCA on Sat Nov 24 22:21:34 2007
