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1eo1
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(New page: 200px<br /><applet load="1eo1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1eo1" /> '''Solution structure of hypothetical protein M...)
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Revision as of 20:28, 24 November 2007
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Solution structure of hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum
Overview
The solution structure of MTH1175, a 124-residue protein from the archaeon, Methanobacterium thermoautotrophicum has been determined by NMR, spectroscopy. MTH1175 is part of a family of conserved hypothetical, proteins (COG1433) with unknown functions which contains multiple paralogs, from all complete archaeal genomes and the archaeal gene-rich bacterium, Thermotoga maritima. Sequence similarity indicates this protein family may, be related to the nitrogen fixation proteins NifB and NifX. MTH1175 adopts, an alpha/beta topology with a single mixed beta-sheet, and contains two, flexible loops and an unstructured C-terminal tail. The fold resembles, that of Ribonuclease H and similar proteins, but differs from these in, several respects, and is not likely to have a nuclease activity.
About this Structure
1EO1 is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.
Reference
NMR structure determination and structure-based functional characterization of conserved hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum., Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA, J Struct Funct Genomics. 2000;1(1):15-25. PMID:12836677
Page seeded by OCA on Sat Nov 24 22:35:35 2007
Categories: Methanothermobacter thermautotrophicus | Single protein | Arrowsmith, C.H. | Cort, J.R. | Kennedy, M.A. | NESG, Northeast.Structural.Genomics.Consortium. | Mixed a/b protein | Mixed beta sheet | Nesg | Northeast structural genomics consortium | Protein structure initiative | Psi | Strand order 321456 | Strands 2 and 6 antiparallel to rest. | Structural genomics
