1n7a

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Revision as of 20:32, 24 November 2007

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spinqualitylabelsall models 1n7a, resolution 1.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

RIP-Radiation-damage Induced Phasing

Overview

The use of third generation synchrotron sources has led to renewed concern, about the effect of ionizing radiation on crystalline biological samples., In general, the problem is seen as one to be avoided. However, in this, paper, it is shown that, far from being a hindrance to successful, structure determination, radiation damage provides an opportunity for, phasing macromolecular structures. This is successfully demonstrated for, both a protein and an oligonucleotide, by way of which complete models, were built automatically. The possibility that, through the exploitation, of radiation damage, the phase problem could become less of a barrier to, macromolecular crystal structure determination is discussed.

About this Structure

1N7A is a Protein complex structure of sequences from [1] with K and SPM as ligands. Full crystallographic information is available from OCA.

Reference

Specific radiation damage can be used to solve macromolecular crystal structures., Ravelli RB, Leiros HK, Pan B, Caffrey M, McSweeney S, Structure. 2003 Feb;11(2):217-24. PMID:12575941

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