1n81
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(New page: 200px<br /><applet load="1n81" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n81, resolution 2.10Å" /> '''Crystal structure of...)
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Revision as of 20:34, 24 November 2007
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Crystal structure of Pfg27 from Plasmodium falciparum
Overview
Malaria transmission is dependent on the development of sexual forms of, Plasmodium falciparum, called gametocytes, in the vertebrate host. Pfg27, is an abundantly expressed sexual stage-specific protein that is essential, for gametocytogenesis in P. falciparum. We describe the crystal structure, of Pfg27, which reveals a novel fold composed of two pseudo dyad-related, repeats of the helix-turn-helix motif. Structurally equivalent helices of, each repeat either form a dimer interface or interact with RNA in vitro., One side of the dimer presents an unprecedented juxtaposition of four, polyproline (PXXP) motifs. Preliminary binding data indicate that these, sites are capable of binding Src homology-3 (SH3) modules. Molecular, modeling suggests that the dimer can accommodate two SH3 modules, simultaneously, potentially enabling molecular crosstalk between, SH3-containing proteins. The structural and initial biochemical evidence, suggests that Pfg27 may serve as a platform for RNA and SH3 binding.
About this Structure
1N81 is a Single protein structure of sequence from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.
Reference
Structure of a gametocyte protein essential for sexual development in Plasmodium falciparum., Sharma A, Sharma I, Kogkasuriyachai D, Kumar N, Nat Struct Biol. 2003 Mar;10(3):197-203. PMID:12577051
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