1afx
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(New page: 200px<br /><applet load="1afx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1afx" /> '''UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR...)
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Revision as of 20:40, 24 November 2007
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UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES
Overview
The hairpin ribozyme is a small catalytic RNA with a unique two-domain, structure. Here we present the solution structure of the loop B domain of, the hairpin ribozyme, which contains most of the catalytically essential, nucleotides. The 38-nucleotide domain contains a 16-nucleotide internal, loop that forms one of the largest non-Watson-Crick segments of base, pairing thus far determined by either NMR or crystallography. Since the, solution structure of the smaller loop A domain has been previously, solved, an NMR structure-based model of the 22,000 Mr hairpin, ribozyme-substrate open complex emerges by joining the two domain, structures. Strikingly, catalytically essential functional groups for the, loop B domain are concentrated within an expanded minor groove, presenting, a clear docking surface for the loop A domain.
About this Structure
1AFX is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Solution structure of the loop B domain from the hairpin ribozyme., Butcher SE, Allain FH, Feigon J, Nat Struct Biol. 1999 Mar;6(3):212-6. PMID:10074938
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