1pfz
From Proteopedia
(New page: 200px<br /> <applet load="1pfz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pfz, resolution 1.85Å" /> '''PROPLASMEPSIN II FR...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1PFZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]] with GOL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.39 3.4.23.39]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PFZ OCA]]. | + | 1PFZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]] with GOL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Hydrolase Hydrolase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.39 3.4.23.39]]. Structure known Active Site: ASP. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PFZ OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: malaria]] | [[Category: malaria]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:25:48 2007'' |
Revision as of 06:21, 30 October 2007
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PROPLASMEPSIN II FROM PLASMODIUM FALCIPARUM
Overview
Proplasmepsin II is the zymogen of plasmepsin II, an aspartic proteinase, used by Plasmodiumfalciparum to digest hemoglobin during the blood stage, of malaria. A large shift between the N-domain and the central and, C-domains of proplasmepsin II opens the active site cleft, preventing the, formation of a functional aspartic proteinase active site. This mode of, inhibition of catalytic activity has not been observed in any other, aspartic proteinase zymogen. Instead of occluding a pre-formed active, site, as in the gastric aspartic proteinase zymogens, the prosegment of, proplasmepsin II interacts extensively with the C-domain and serves as a, 'harness' to keep the domains apart. Disruption of key salt bridges at low, pH may be important in activation.
About this Structure
1PFZ is a [Single protein] structure of sequence from [Plasmodium falciparum] with GOL as [ligand]. Active as [Hydrolase], with EC number [3.4.23.39]. Structure known Active Site: ASP. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum., Bernstein NK, Cherney MM, Loetscher H, Ridley RG, James MN, Nat Struct Biol. 1999 Jan;6(1):32-7. PMID:9886289
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