1nbw
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="1nbw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nbw, resolution 2.4Å" /> '''Glycerol dehydratase ...)
Next diff →
Revision as of 20:47, 24 November 2007
|
Glycerol dehydratase reactivase
Overview
The function of glycerol dehydratase (GDH) reactivase is to remove damaged, coenzyme B(12) from GDH that has suffered mechanism-based inactivation., The structure of GDH reactivase from Klebsiella pneumoniae was determined, at 2.4 A resolution by the single isomorphous replacement with anomalous, signal (SIR/AS) method. Each tetramer contains two elongated 63 kDa alpha, subunits and two globular 14 kDa beta subunits. The alpha subunit contains, structural features resembling both GroEL and Hsp70 groups of chaperones, and it appears chaperone like in its interactions with ATP. The fold of, the beta subunit resembles that of the beta subunit of glycerol, dehydratase, except that it lacks some coenzyme B(12) binding elements. A, hypothesis for the reactivation mechanism of reactivase is proposed based, on these structural features.
About this Structure
1NBW is a Protein complex structure of sequences from Klebsiella pneumoniae with CA as ligand. Full crystallographic information is available from OCA.
Reference
Structure of glycerol dehydratase reactivase: a new type of molecular chaperone., Liao DI, Reiss L, Turner I, Dotson G, Structure. 2003 Jan;11(1):109-19. PMID:12517345
Page seeded by OCA on Sat Nov 24 22:54:30 2007
