User:Tilman Schirmer/Sandbox 201
From Proteopedia
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== Intro == | == Intro == | ||
| - | PleD from ''Caulobacter crescentus'' is a response regulator with an unorthodox catalytic, diguanylate cyclase, output domain. It is composed of a canonical CheY-like response regulator receiver (Rec) domain, a Rec-like (Rec') adaptor domain, and a C-terminal GGDEF domain that | + | PleD from ''Caulobacter crescentus'' is a response regulator with an unorthodox catalytic, diguanylate cyclase, output domain. It is composed of a canonical CheY-like response regulator receiver (Rec) domain, a Rec-like (Rec') adaptor domain, and a C-terminal GGDEF domain that confers the catalytic acitvity. |
| - | [[Image:Pled_domains_1.jpg| | + | [[Image:Pled_domains_1.jpg|left]] |
<applet load='1w25' scene='User:Tilman_Schirmer/Sandbox_201/Protomer/5' size='300' frame='true' align='right' caption='Diguanylate cyclase PleD (1w25)' /> | <applet load='1w25' scene='User:Tilman_Schirmer/Sandbox_201/Protomer/5' size='300' frame='true' align='right' caption='Diguanylate cyclase PleD (1w25)' /> | ||
Revision as of 19:53, 20 June 2009
PleD
Contents |
Intro
PleD from Caulobacter crescentus is a response regulator with an unorthodox catalytic, diguanylate cyclase, output domain. It is composed of a canonical CheY-like response regulator receiver (Rec) domain, a Rec-like (Rec') adaptor domain, and a C-terminal GGDEF domain that confers the catalytic acitvity.
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Substrate binding site
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Allosteric product binding site
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C-di-GMP
Primary inhibition site (Ip)
Secondary inhibition site (Is)
Primary and secondary inhibition sites
Two conformations
non-activated (1w25)
activated (BeF3- modified; 2v0n)
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Non-activated conformation
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: , ,
Activated conformation
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