User:Tilman Schirmer/Sandbox 201

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(Intro)
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== Intro ==
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PleD from ''Caulobacter crescentus'' is a response regulator with an unorthodox catalytic, diguanylate cyclase, output domain. It is composed of a canonical CheY-like response regulator receiver (Rec) domain, a Rec-like (Rec') adaptor domain, and a C-terminal GGDEF domain that confers the catalytic acitvity.
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<scene name='User:Tilman_Schirmer/Sandbox_201/Protomer/5'>PleD</scene>
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from ''Caulobacter crescentus'' is a response regulator with an unorthodox catalytic, diguanylate cyclase, output domain. It is composed of a canonical CheY-like response regulator receiver (<scene name='User:Tilman_Schirmer/Sandbox_201/Protomer/7'>Rec</scene>) domain,
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a Rec-like (scene name='User:Tilman_Schirmer/Sandbox_201/Protomer_rec_prime/2'>Rec'</scene>) adaptor domain,
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and a C-terminal <scene name='User:Tilman_Schirmer/Sandbox_201/Protomer_ggdef/1'>GGDEF</scene> domain that confers the catalytic acitvity.

Revision as of 19:55, 20 June 2009

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PleD



from Caulobacter crescentus is a response regulator with an unorthodox catalytic, diguanylate cyclase, output domain. It is composed of a canonical CheY-like response regulator receiver () domain, 

a Rec-like (scene name='User:Tilman_Schirmer/Sandbox_201/Protomer_rec_prime/2'>Rec'</scene>) adaptor domain, and a C-terminal domain that confers the catalytic acitvity.


Diguanylate cyclase PleD (1w25)

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Contents

Substrate binding site

2v0n

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Allosteric product binding site

Allosteric product binding site

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C-di-GMP


Primary inhibition site (Ip)


Secondary inhibition site (Is)


Primary and secondary inhibition sites





Two conformations

non-activated (1w25)
non-activated (1w25)
activated (BeF3- modified; 2v0n)
activated (BeF3- modified; 2v0n)


non-activated (1w25)

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activated (BeF3- modified; 2v0n)

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Non-activated conformation

1w25

1w25

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: , ,



















Activated conformation

2v0n

2v0n

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Tilman Schirmer

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