User:Tilman Schirmer/Sandbox 201
From Proteopedia
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| - | <applet load='2v0n' scene='User:Tilman_Schirmer/Sandbox_201/Substrate_binding_site/ | + | <applet load='2v0n' scene='User:Tilman_Schirmer/Sandbox_201/Substrate_binding_site/4' size='300' frame='true' align='right' caption='Diguanylate cyclase PleD (2v0n)' /> |
Revision as of 20:50, 20 June 2009
PleD
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Intro
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from Caulobacter crescentus is a response regulator with an unorthodox catalytic, diguanylate cyclase, output domain. It is composed of a canonical CheY-like response regulator receiver () domain,
a Rec-like () adaptor domain,
and a C-terminal domain that confers the catalytic acitvity.
The GGDEF domain is named after the highly conserved (in PleD it is GGEEF) that locates to a β-hairpin.
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The motif is part of the as identified in the structure of PleD in complex with .
Allosteric product binding site
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C-di-GMP
Primary inhibition site (Ip)
Secondary inhibition site (Is)
Primary and secondary inhibition sites
Two conformations
non-activated (1w25)
activated (BeF3- modified; 2v0n)
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Non-activated conformation
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: , ,
Activated conformation
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