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1j3l

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(New page: 200px<br /><applet load="1j3l" size="450" color="white" frame="true" align="right" spinBox="true" caption="1j3l, resolution 2.30&Aring;" /> '''Structure of the RNA...)
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Revision as of 20:55, 24 November 2007

Image:1j3l.gif

1j3l, resolution 2.30Å

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Structure of the RNA-processing inhibitor RraA from Thermus thermophilis

Overview

The menG gene product, thought to catalyze the final methylation in, vitamin K(2) synthesis, has recently been shown to inhibit RNase E in, Eschericha coli. The structure of the protein, since renamed RraA, has, been solved to 2.3 A using the multiple-wavelength anomalous diffraction, method and selenomethionine-substituted protein from Thermus thermophilus., The six molecules in the asymmetric unit are arranged as two similar, trimers which have a degree of interaction, suggesting biological, significance. The fold does not support the postulated methylation, function. Genomic analysis, specifically a lack of an RNase E homologue in, cases where homologues to RraA exist, indicates that the function is still, obscure.

About this Structure

1J3L is a Single protein structure of sequence from Thermus thermophilus with MG and CL as ligands. Full crystallographic information is available from OCA.

Reference

Structure of the RNA-processing inhibitor RraA from Thermus thermophilis., Rehse PH, Kuroishi C, Tahirov TH, Acta Crystallogr D Biol Crystallogr. 2004 Nov;60(Pt 11):1997-2002. Epub, 2004 Oct 20. PMID:15502308

Page seeded by OCA on Sat Nov 24 23:02:42 2007

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