1ngt
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(New page: 200px<br /><applet load="1ngt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ngt, resolution 2.04Å" /> '''The Role of Minor Gr...)
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Revision as of 20:59, 24 November 2007
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The Role of Minor Groove Functional Groups in DNA Hydration
Overview
Here we describe the crystal structure of modified [d(CGCGAATTCGCG)]2, refined to 2.04 A. The modification, which affects only the two thymines, at the central ApT step, involves isosteric removal of the 2-keto oxygen, atoms and substitution of the N1 nitrogen with carbon. The crystal, structure reveals the ability of this modified thymine to effectively base, pair with adenine in [d(CGCGAAtTCGCG)]2. The structure also suggests that, the minor groove 'spine of hydration' is destabilized but essentially, intact.
About this Structure
1NGT is a Protein complex structure of sequences from [1] with MG as ligand. Full crystallographic information is available from OCA.
Reference
The role of minor groove functional groups in DNA hydration., Woods KK, Lan T, McLaughlin LW, Williams LD, Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:12595562
Page seeded by OCA on Sat Nov 24 23:06:58 2007
